Is Wegovy the Solution for Childhood Obesity?

There are numerous approved treatments for childhood obesity. However, when it comes to effectiveness, clinicians have limited options besides bariatric surgery, with semaglutide being one of the most effective tools.

Wegovy for childhood obesity?

Unveiling the Complexity of the Disease and the Potential of Semaglutide

By [Your Name], Medical Care, Dietary Health, and Mental Health Expert

Megan Kelsey, MD

Childhood obesity is a multifaceted issue that requires a thorough understanding to formulate effective solutions. As Megan Kelsey, MD, the medical director of lifestyle medicine and adolescent bariatric surgery at Children’s Hospital Colorado, explains, it’s a complex interplay of genetic, physiological, socioeconomic, and environmental factors that contribute to this epidemic. Many misconceptions surround childhood obesity, stigmatizing the disease and creating barriers to treatment.

In the United States alone, a staggering 15 million children and adolescents battle obesity, and contrary to common belief, they do not simply outgrow it. High blood pressure, diabetes, liver disease, sleep apnea, and mental health issues are just a few of the severe health consequences that can arise if left untreated. It can even become a risk factor for premature death. With limited treatment options available, medical professionals have turned to semaglutide as a potential game-changer.

Semaglutide: Weighing the Risks and Benefits

Semaglutide, a medication approved for weight management, mimics the glucagon-like peptide-1 (GLP-1) hormone produced in the intestines, effectively controlling appetite and cravings. While our natural GLP-1 dissipates quickly, semaglutide exhibits prolonged effects.

Initially used to treat diabetes as Ozempic and Rybelsus, semaglutide gained attention in 2021 for its potential in weight loss. Success stories shared by social media influencers and entertainers such as Tracy Morgan, Sharon Osbourne, and Oprah Winfrey only fueled the demand. Financial analysts predict weight loss drugs like Wegovy, a brand name for semaglutide, could blossom into a $100 billion market by 2030.

Studies have shown that individuals taking semaglutide can sustain a remarkable 15% reduction in body weight. This is highly encouraging since even modest weight loss of 5%-10% can significantly improve overall health and quality of life.

Early Intervention for Better Outcomes

As with many illnesses, early intervention holds the key to better treatment outcomes for obesity. Research conducted in December 2022, published in the New England Journal of Medicine, revealed impressive results in children receiving semaglutide injections. Over a period of 68 weeks, combined with lifestyle counseling, participants achieved an average 16% reduction in body mass index. This treatment also led to improvements in waist size, cholesterol levels, triglycerides, and other health indicators. Interestingly, semaglutide appears to be even more effective in children than in adults, though further research is required to uncover the underlying reasons.

According to Aaron Kelly, PhD, co-director of the Center for Pediatric Obesity Medicine at the University of Minnesota Medical School, the only treatment more effective than semaglutide is bariatric surgery, which is far riskier and more invasive. In fact, almost 45% of children participating in the New England Journal of Medicine study witnessed their weight drop below the obesity baseline. Consequently, the American Academy of Pediatrics (AAP) recommended semaglutide, alongside exercise and nutrition counseling, as a potential treatment option for children aged 12 and older with obesity.

While semaglutide exhibits side effects such as nausea, vomiting, and diarrhea, these are commonly observed with many widely used medications. Concerns regarding decreased muscle mass, bone density, and rare cases of serious side effects like gallstones or pancreatitis have also been raised. Long-term effects on a developing brain remain uncertain and necessitate further investigation. However, the risks must be weighed against the severe consequences of untreated obesity.

It’s essential for healthcare providers to ensure individuals and their parents fully understand the side effects. Semaglutide alone cannot yield miracles. The AAP guidelines emphasize the importance of exercise and improved diets alongside the medication. Semaglutide serves as a foundation, helping patients level the playing field and foster healthier habits.

A Forever Drug?

Clinical studies have shown that adults using Wegovy tend to regain approximately two-thirds of their lost weight within a year of discontinuing the drug. This raises the possibility that children may need to rely on semaglutide for life. Amanda Velazquez, MD, director of obesity medicine at Cedars-Sinai Center for Weight Management and Metabolic Health, draws parallels with other chronic conditions such as type 2 diabetes, asthma, and high cholesterol, where long-term medication use is necessary.

While some may express concerns about the side effects, Dr. Velazquez reassures us that they are typical for this type of medication. In fact, semaglutide’s side effects for obesity patients are no different from those experienced by diabetes patients who have been using the drug for several years. However, the steep monthly price tag of around $1,400 could make it unaffordable for many families. Insurance companies are often reluctant to cover semaglutide for weight loss alone, but as generic versions become available, accessibility may improve. In the meantime, pharmaceutical companies are actively developing alternative weight loss drugs.

Moving Past the Stigma of Childhood Obesity

Stigma and ignorance surrounding semaglutide and childhood obesity can be significant hurdles, impeding progress among patients, parents, and even healthcare providers. Dr. Velazquez notes that there is sometimes an expectation for children to “prove themselves” before receiving medications like semaglutide. However, this approach contradicts medical practices for diseases such as type 2 diabetes, high blood pressure, or heart attacks. Disregarding and not treating obesity based on such prerequisites would constitute malpractice.

The AAP guidelines explicitly acknowledge the damaging impact of stigma on individuals with obesity. This stigma often deters patients from seeking medical attention due to the fear of judgment. To combat this, healthcare providers must grasp the significance of social and environmental determinants of childhood obesity and raise awareness among their peers.

During consultations, Dr. Kelsey takes a holistic approach. She de-emphasizes weight as the sole metric of health, encouraging young patients and their parents to understand that obesity is a complex, chronic disease and not a moral failing. Medications like Wegovy represent just one potential avenue towards improved health. Dr. Kelsey reminds her patients that although self-motivation is essential, seeking a little help in achieving long-lasting positive health changes is perfectly acceptable.


📚 References

  1. American Academy of Pediatrics. Clinical Practice Guideline for the Management of Overweight and Obesity in Children and Adolescents. Pediatrics. 2017;140(2):e20171985.
  2. Franciscy D. Wegovy (Semaglutide) for Obesity: What Do We Know Now?. Northwest Primary Care. 2022.
  3. Stanford Children’s Health – Pediatric Weight Clinic. Childhood Obesity Treatment Options. Stanford Children’s Health.
  4. Kelly AS, Repaske DR. Update on the Science and Clinical Trials in Pediatric Obesity. New England Journal of Medicine. 2022;386(8):728-731.
  5. National Institute of Diabetes and Digestive and Kidney Diseases. Treatment of Childhood Obesity. NIDDK.